SSA1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1739.13, also known as SSA1 or SSA2, encodes a member of the Hsp70 family of molecular chaperones on chromosome 3 of Schizosaccharomyces pombe. The product possesses ATP hydrolase activity, binds ATP and heat shock proteins, and is annotated as a protein folding chaperone and transcriptional co-regulator. This gene is associated with cellular response to heat, protein refolding, proteasome assembly, microtubule assembly, nuclear transport, mRNA metabolism, exocytosis, TCA cycle, sterol anabolism, and sexual reproduction. It localizes to the cytoplasm, nucleus, cytosol, plasmalemma, and protein aggregate centers. The gene is associated with increased thermotolerance, altered cell cycle progression, abnormal pheromone sensitivity and recovery, premature apoptosis, increased polyploidy, decreased cytokinesis rate, and altered prion inheritance. It is also associated with oxidative stress response.