mad3 — Schizosaccharomyces pombe 972h-

Summary

SPCC1795.01C (mad3) on chromosome 3 of Schizosaccharomyces pombe 972h- encodes a protein with ubiquitin ligase inhibitor activity, histone H2A kinase activity, protein serine/threonine kinase activity, and APC binding, and belongs to the Mad3/Bub1_I and Bub1/Mad3 domain families. The gene is associated with the spindle assembly checkpoint, mitotic checkpoint, MCC assembly, meiosis I spindle assembly checkpoint, downregulation of the mitotic metaphase/anaphase transition, centromeric meiotic sister chromatid cohesion, homologous chromosome segregation, anaphase cohesion protection, chromosome condensation, spindle orientation, microtubule dynamics, and protein positioning. It localises to the kinetochore, MCC, Bub1-Bub3 complex, mitotic spindle pole body, centromere complex, and cytosol. Related genes in other species link the family to mitotic checkpoint functions.