SNF2 — Schizosaccharomyces pombe 972h-

Summary

SNF2 (snf22) on chromosome 3 of Schizosaccharomyces pombe encodes a protein with ATP-dependent chromatin remodeler activity, helicase activity, histone binding, and DNA translocase activity. It is associated with nucleosome organization, disassembly, meiotic prophase I, kinetochore assembly, and the spindle checkpoint. The gene is linked to the SHREC and PBAF complexes, heterochromatin islands, and centromere binding. Phenotypic associations include increased thermotolerance, altered cell cycle progression through G1/S and G2/M transitions, increased transposable element transposition, and abnormal cell fusion. It is also associated with carbon source utilization, mating-type switching, and pexophagy. Related genes in other species link it to the SWI-SNF complex and oxidative stress response.