BDF1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1450.02 (BDF1) on chromosome 3 of Schizosaccharomyces pombe encodes a bromodomain-containing chromatin reader protein. The gene product is a histone reader with specificity for acetylated histone H4 (K12, K16) and H3 (K56) marks, possesses histone acetyltransferase activity toward H3 (K9, K14, K18), and is a transcriptional co-regulator binding TFIID-class factors and core promoter DNA. BDF1 is associated with chromatin decompaction, heterochromatin boundary formation, meiotic drive, DNA replication and damage checkpoints, and positive regulation of RNA polymerase II transcription elongation. The protein localizes to multiple chromatin-modifying complexes including SAGA, ADA, SALSA, and SWR-C. Phenotypic associations link BDF1 to meiosis, spore germination, cell cycle progression through M phase and S phase, stress responses including hyperosmotic stress resistance and thermotolerance, biofilm formation, telomere length maintenance, and aneuploidy.