spc7 — Schizosaccharomyces pombe 972h-

Summary

SPCC1020.02 (spc7) in Schizosaccharomyces pombe 972h- on chromosome 3 encodes the kinetochore protein knl1, a member of the Spc105/Spc7 family with a Knl1_RWD_C domain. The product exhibits kinetochore adaptor activity, signaling adaptor activity, and microtubule plus-end binding. It is associated with kinetochore assembly, localization to the outer kinetochore and centromere region, and attachment of spindle microtubules to mitotic chromosomes. The gene is linked to spindle assembly checkpoint function, including MCC assembly and MAD, as well as chromosome biorientation, mitotic sister chromatid biorientation, and anaphase cohesion protection. It is associated with meiotic processes such as homologous chromosome orientation in meiotic metaphase I, meiosis I, and upregulation of the meiosis I spindle assembly checkpoint. Studies of related genes in other species link it to the KNL1 complex.