NMT1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1223.02 (NMT1) on chromosome 3 of Schizosaccharomyces pombe encodes a member of the NMT1/THI5 and SsuA/THI5 domain families, with 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase activity from histidine and PLP, and metal binding. This gene is associated with thiamin metabolism, TPP biosynthesis, thiamin transport, and thiamin anabolism, as well as ergothioneine, selenoneine, polyamine, and vitamin A anabolism. It is also linked to sucrose metabolism, response to iron, cell cycle checkpoint, G2 phase, cell size control, cell polarization, nuclear import, nucleus organization, hearing, and digestion. The product localizes to the cytosol and nucleus. Studies of related genes in other species connect the family to decreased sporulation, abnormal vacuolar morphology, decreased vegetative growth and competitive fitness, and decreased chemical resistance.