tea1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1223.06 (tea1) on chromosome 3 of Schizosaccharomyces pombe encodes a protein membrane adaptor containing Kelch-type beta-propeller domains. This gene is associated with monopolar cell growth, microtubule-based transport, cell migration, and cell activation. It is linked to microtubule stabilization and dynamics, including microtubule shortening, as well as actin depolymerization. Tea1 is associated with the establishment or maintenance of bipolar cell polarity, cell growth mode switching from monopolar to bipolar, and regulation of cell shape. It has been associated with spore wall assembly, G2 phase, the septation initiation network (SIN), and appressorium formation. The protein localizes to microtubule ends, cortical and cytoplasmic microtubule plus-ends, growing and non-growing cell tips, static microtubule bundles, the division septum, and the microtubule cytoskeleton. Studies of related genes in other species link the family to cell polarity and microtubule organization.