HST2 — Schizosaccharomyces pombe 972h-

Summary

SPCC132.02 (HST2) on chromosome 3 of Schizosaccharomyces pombe encodes a class I sirtuin family protein with NAD-dependent histone deacetylase activity, including activity toward histones H3K4, H3K9, H3K14 and H4K16, and is classified as EC 2.3.1.286. The gene is associated with epigenetic regulation of gene expression, chromatin silencing at telomeres, centromeres, rDNA and mating-type regions, and heterochromatin island assembly. It is linked to suppression of mitotic and telomeric recombination, DNA damage response, regulation of cell differentiation, cell wall biogenesis, phenotypic switching, mating, and cellular response to oxygen levels. The protein localises to nuclear lumen, chromatin, telomeric and subtelomeric heterochromatin, centric heterochromatin, and the SET3C. Phenotypic associations include abnormal carbon source utilisation, cell cycle arrest at G1/S and S phases, absent anaerobic and fermentative growth, altered chronological lifespan, abnormal telomere length, and defective vacuolar distribution and transport.