LAP2 — Schizosaccharomyces pombe 972h-

Summary

SPCC1322.05C, also known as LAP2 in Schizosaccharomyces pombe 972h- on chromosome 3, encodes a protein with peptidase M1 and leukotriene-A4 hydrolase domains, and is associated with metalloaminopeptidase, epoxide hydrolase, and leukotriene-A4 hydrolase activities. The gene is associated with diverse biological processes including pore formation, galactose-specific flocculation, peptide breakdown, regulation of filamentous growth, cytoplasm-to-vacuole targeting via the NVT pathway, nuclear pore complex assembly, cell wall assembly, nucleocytoplasmic transport, response to oxidative stress, cell cycle modulation, and invasive growth. It localizes to the multivesicular body, fungal-type vacuole lumen, cytosol, and nucleus. Studies of related genes in other species link the LAP2 family to altered thermotolerance, vegetative growth rate, vacuolar morphology, competitive fitness, and chemical resistance.