COY1 — Schizosaccharomyces pombe 972h-

Summary

SPCC1322.12C (COY1, also known as bub1) on chromosome 3 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with histone H2A kinase activity, belonging to the Mad3/Bub1_I and Bub1/Mad3 families. The gene is associated with mitotic and meiotic spindle assembly checkpoint functions, including metaphase chromosome alignment, MCC assembly, chromosome segregation regulation, and centromere localization. It is linked to the outer and inner kinetochore, the Bub1-Bub3 complex, and the mitotic spindle pole body. Phenotypic associations include abnormal protein transport and secretion, altered vacuolar transport, Golgi morphology defects, mitotic cell cycle arrest, decreased invasive growth, increased sporulation efficiency, and abnormal endomembrane system morphology. Studies of related genes in other species connect the family to vesicle-mediated transport and Golgi function, while sequence similarity links extend to iron and potassium concentration traits.