GAP1 — Schizosaccharomyces pombe 972h-

Summary

SPBPB2B2.01 (GAP1) on chromosome 2 of Schizosaccharomyces pombe encodes an uncharacterized amino-acid permease belonging to the APC/YAT family, with experimentally confirmed L-arginine and L-lysine transporter activity. The gene is associated with basic amino acid transport, including L-lysine, L-leucine, and L-arginine import, as well as cell-cell fusion, regulation of growth, Ras protein signal transduction, replication fork arrest, cytokinesis regulation, nucleosome assembly, nitrogen utilization, and stress response. It localizes to the plasma membrane at cell tips, medial membrane band, Golgi, ER, and fungal-type vacuole. Phenotypic associations include altered nutrient uptake, endocytosis, sporulation, cell cycle progression, hydrostatic pressure resistance, carbon and sulfur source utilization, adhesion, and replicative lifespan. Studies of related genes in other species link the family to phosphate content and oxidative stress response.