CDC68 — Schizosaccharomyces pombe 972h-

Summary

SPBP8B7.19 (symbol CDC68, preferred name spt16) in Schizosaccharomyces pombe 972h- on chromosome 2 encodes the Spt16 subunit of the FACT complex, a histone chaperone with H2A-H2B histone carrier activity, nucleosome binding, and histone binding. The gene is associated with regulation of DNA-templated transcription elongation, nucleosome disassembly and assembly, heterochromatin organization, constitutive heterochromatin assembly, chromatin silencing, and regulation of sister chromatid cohesion. It localizes to the FACT complex, transcription elongation factor complex, euchromatin, and nucleus. Phenotypic associations include delayed cell cycle progression in mid-anaphase and G2 phase, increased sporulation rate, increased transposable element transposition, delayed growth in exponential phase, and increased virulence.