ATG8 — Schizosaccharomyces pombe 972h-

Summary

SPBP8B7.24C (ATG8) on chromosome 2 of Schizosaccharomyces pombe encodes a member of the Atg8-like ubiquitin-like domain family with phosphatidylethanolamine binding activity. The gene is associated with macroautophagy, mitophagy, ER-phagy, nucleophagy, membrane fusion and fission, vacuole organization and fusion, sporulation, anatomical structure formation involved in morphogenesis, cellular response to nitrogen starvation, vacuolar protein sorting, protein transport, protein folding, cell death, innate immunity, immune response, and virus-induced PTGS. It localizes to the phagophore assembly site (PAS), cytoplasmic vesicles, Cvt vesicle membrane, fungal-type vacuole and its membrane, cytoplasm, cytosol, and nucleus. Phenotypic associations include abnormal or absent autophagy, nucleophagy, pexophagy, nuclear import, cell cycle progression, and lifespan, as well as delayed vegetative growth and increased fermentative growth.