RTS1 — Schizosaccharomyces pombe 972h-

Summary

SPBP16F5.03C (RTS1, tra1) on chromosome 2 of Schizosaccharomyces pombe encodes a protein serine/threonine kinase with ATP-binding activity that also has structural molecule activity and chromatin adaptor activity. The protein contains Tra1_central, Tra1_ring, DDR_Repair_Kinase, PIK-rel_kinase_FAT, and PI3/4_kinase_cat_dom domains. RTS1 is associated with DNA replication termination, replication fork arrest and processing, DNA damage response signal transduction, DNA condensation, chromatin remodeling, gene conversion, mating-type switching, regulation of autophagy, intracellular transport, transcription upregulation, developmental processes, metaphase, biofilm formation, filamentous growth, and leucine uptake. It localises to the TIP60 histone acetylase complex, SWR-C, chromatin, chromosomes, and the nucleus. Phenotypic associations include altered cell cycle progression, autophagy, pexophagy, mating-type switching, X-ray resistance, meiosis timing, sporulation efficiency, osmotic and alkaline pH stress resistance, and prion inheritance.