SEC23 — Saccharomyces cerevisiae S288c

Summary

YPR181C in Saccharomyces cerevisiae S288c encodes a protein with GTPase-activating protein (GAP) activity and zinc-binding capability, belonging to the Sec23/24 family of COPII vesicle coat components. The gene product is localised to the ER exit site, COPII vesicle coat, Golgi membrane, and ER membrane, and is associated with vesicle fusion, formation, and transport, particularly ER-to-Golgi transport, cargo loading into COPII vesicles, and regulation of COPII vesicle coating. It is linked to ceramide transport, membrane tubulation, vacuolar protein sorting, cytokinesis, lipogenesis, RNA anabolism, and secretion. Associations with traits include oxidative stress, and phenotypes linked to the gene include decreased protein secretion, autophagy, thermotolerance, UV resistance, and vegetative growth, as well as abnormal ER and nucleolar morphology, and inviability. Related genes in other species link the family to similar vesicle trafficking processes.