ATG13 — Saccharomyces cerevisiae S288c

Summary

YPR185W in Saccharomyces cerevisiae S288c encodes a protein with armadillo domain binding, protein kinase regulator activity and lipid binding, and belongs to the Atg13_N and HORMA domain superfamilies. The gene is associated with the regulation of autophagy, including macroautophagy, microautophagy, ER-phagy, mitophagy and aggrephagy, as well as protein targeting to the vacuole involved in autophagy, TORC1 signaling, response to starvation, glucose homeostasis, vesicle formation, and NVJ assembly. It localises to the PAS complex, ULK complex, vacuole-IM contact site and cytosol. Phenotypic associations include absent autophagy, decreased mitophagy and reticulophagy, decreased chronological lifespan and vegetative growth, abnormal nuclear morphology, absent sporulation, increased invasive growth, and altered resistance to chemicals and metals. Related genes in other species link the family to autophagy regulation.