CCR4 — Saccharomyces cerevisiae S288c

Summary

YAL021C encodes a protein with poly(A)-specific RNase and 3'-5' exoribonuclease activities, also capable of RNA and metal binding. It is a component of the CCR4-NOT complex and Paf1 complex, localizing to the cytoplasm, cytosol, nucleus, and P bodies. The gene is associated with numerous biological processes including RNA breakdown, cellular senescence, microautophagy, response to cadmium and iron, protein ubiquitination, nucleocytoplasmic transport, and cellular response to starvation. It has been linked to traits such as zinc sensitivity, phosphate content, oxidative stress, and acid sensitivity. Phenotypic associations include altered cell size and shape, decreased sporulation efficiency, increased chronological lifespan, decreased replicative lifespan, abnormal budding patterns, and changes in anaerobic, respiratory, and fermentative growth rates. Related genes in other species are linked to reduced virulence.