FUS3 — Saccharomyces cerevisiae S288c

Summary

YBL016W (FUS3) on Saccharomyces cerevisiae chromosome II encodes a protein with ERK1-type protein serine/threonine kinase activity and ATP binding. The gene is associated with the MAPK cascade, pheromone response, mating behavior, cell-cell fusion, chemotropism, pseudohyphal and invasive hyphae formation, regulation of autophagy, TORC1 signaling, transposition, and mitotic cell cycle G1 arrest in response to pheromone. It is linked to seed maturation and pigment accumulation, as well as traits including vivipary and oxidative stress. The product localizes to the cytoplasm, cytosol, nucleus, and mitotic spindle pole body. Studies of related genes in other species link the family to loss of pathogenicity and reduced virulence.