SSA3 — Saccharomyces cerevisiae S288c

Summary

YBL075C (SSA3) on chromosome II of Saccharomyces cerevisiae encodes a member of the Hsp70 family of ATP-dependent protein folding chaperones. The product binds ATP, unfolded proteins, and other heat shock proteins, and exhibits ATP hydrolase activity. SSA3 is associated with the regulation of protein folding, the response to desiccation, and the release of cytochrome c from mitochondria. It has been connected to biofilm formation, developmental induction, and the regulation of host defenses. The gene is linked to traits including glucose, hydrogen peroxide, and protein content, as well as iron concentration and acid sensitivity. Phenotypic associations include decreased cold sensitivity, increased chronological lifespan, and altered resistance to chemicals. Studies of related genes in other species support a conserved role in stress responses and protein homeostasis.