REB1 — Saccharomyces cerevisiae S288c

Summary

YBR049C (REB1) on chromosome II of Saccharomyces cerevisiae encodes a DNA-binding transcription factor with RNA polymerase II-specific activator activity, and it binds sequence-specifically to DNA, including transcription termination sites and cis-regulatory regions. The protein is localised to the nucleus, rDNA heterochromatin, and the NuR complex. REB1 is associated with site-specific DNA replication termination at the RTS1 barrier, replication fork arrest in rDNA repeats, RNA polymerase I transcription termination, and nucleosome organisation. It has been linked to cell cycle processes, triglyceride mobilisation, isoleucine and lipid A anabolism, response to arsenic, and adiposome formation. Phenotypic associations include decreased filamentous and invasive growth, reduced replicative lifespan and chromosome maintenance, increased toxin resistance, heat sensitivity, and inviability. Studies of related genes in other species link the family to similar replication fork barrier functions.