VPS15 — Saccharomyces cerevisiae S288c

Summary

YBR097W in Saccharomyces cerevisiae S288c encodes a protein with protein serine/threonine kinase activity and ubiquitin binding capability, containing Vps15-like, WD40 repeat, and HEAT repeat domains. The gene is associated with vacuolar protein sorting, late endosome-to-vacuole transport, vacuole inheritance, vesicle fusion, exocytosis, and protein and lipid phosphorylation. It is linked to the phosphatidylinositol 3-kinase complex class III, the spindle midzone, and the nucleus-vacuole junction. Associations with traits include zinc sensitivity, potassium concentration, light sensitivity, acid sensitivity, and oxidative stress. Phenotypic associations include decreased protein transport, abnormal vacuolar morphology, absent autophagy, decreased biofilm formation, decreased chronological lifespan, decreased vegetative growth, increased heat sensitivity, and decreased resistance to acid, alkaline pH, hyperosmotic stress, and metals. Studies of related genes in other species link the family to reduced virulence.