ARL1 — Saccharomyces cerevisiae S288c

Summary

YBR164C in Saccharomyces cerevisiae S288c encodes a protein membrane adaptor with GTPase activity and GTP binding, and contains a small GTPase ARF/SAR family domain. It is associated with vesicle tethering, endosomal transport, Golgi localization, vesicle formation, membrane organization, and regulated exocytosis. The gene is linked to numerous phenotypes including decreased protein and vacuolar transport, absent or decreased autophagy, decreased viability, reduced stress resistance (hyperosmotic, oxidative, heat), decreased vegetative growth and competitive fitness, altered chemical compound accumulation, and abnormal vacuolar morphology. Traits associated with YBR164C include germination rate, potassium concentration, salt sensitivity, oxidative stress, light sensitivity, and acid sensitivity. The protein localizes to the mitochondria-associated membrane, ER exit site, COPII vesicle coat, Golgi membrane, microtubule cytoskeleton, and cell cortex.