RIF1 — Saccharomyces cerevisiae S288c

Summary

YBR275C (RIF1) in Saccharomyces cerevisiae S288c encodes a protein containing an N-terminal Rif1_N domain. The gene is associated with telomere maintenance, organization, and capping, as well as DNA recombination, replication, damage response, and canonical nonhomologous end joining. It is also linked to replicative and cellular senescence, mating, detoxification, and deoxyribonucleotide anabolism. Phenotypic associations include increased telomere length and silencing, decreased replicative lifespan and vegetative growth, abnormal chromosome maintenance, and changes in chemical resistance. The gene is also associated with oxidative stress and abnormal protein modification and activity.