TRX3 — Saccharomyces cerevisiae S288c

Summary

YCR083W, also known as TRX2 or TRX3, encodes a thioredoxin family protein with protein-disulfide reductase and antioxidant activities. The gene is associated with the detection of oxidative stress, regulation of protein oxidation, and cellular detoxification of hydrogen peroxide. It has been linked to ultradian rhythm, cytokinesis, glycosylation, proteolysis, and NADP metabolism, as well as hexose and glucoside transport, sulfate assimilation, and amino acid anabolism including alanine and methionine metabolism. TRX2 is associated with biomass yield and oxidative stress traits, and phenotypes include altered chemical compound accumulation, vacuolar morphology abnormalities, and changes in competitive fitness and chemical resistance. The protein localizes to the cytoplasm, cytosol, nucleus, mitochondria, and vacuole. Related genes in other species link the family to similar redox regulatory functions.