SIR2 — Saccharomyces cerevisiae S288c

Summary

YDL042C in Saccharomyces cerevisiae S288c encodes a sirtuin-family NAD-dependent histone deacetylase, with activity toward histone H3K4, H3K9, H3K14 and H4K16 residues. The protein localises to chromatin, including subtelomeric, rDNA and mating-type region heterochromatin, and is a component of the SET3C complex. It is associated with protein deacetylation, chromatin silencing, rDNA packaging, DNA condensation, sexual reproduction, adaptive thermogenesis, gluconeogenesis, programmed cell death, and detoxification of arsenic. The gene is linked to numerous phenotypes including increased mitotic recombination, increased mutation frequency, decreased silencing, decreased replicative lifespan, increased cell size, decreased sporulation and mating efficiency, altered RNA accumulation and localisation, and increased resistance to ionic stress, killer toxin and innate thermotolerance. Studies of related genes in other species link the family to protein deacylase activity (EC 2.3.1.286).