THI3 — Saccharomyces cerevisiae S288c

Summary

YDL080C (PDC1/THI3) on chromosome IV of Saccharomyces cerevisiae S288c encodes a pyruvate decarboxylase with pyruvate decarboxylase activity, binding thiamine pyrophosphate and magnesium. The gene is associated with regulation of thiamine anabolism, thiamine anabolism, cellular homeostasis, homofermentation, vanillin anabolism, ethanol fermentation, butanediol anabolism, self proteolysis, chorismate metabolism, ROS metabolic process, glycolytic fermentation, D-xylose fermentation, aromatic amino acid family catabolic process to alcohol via Ehrlich pathway, valine breakdown, fructose uptake, regulation of gluconeogenesis, 1-butanol anabolism, and thiamine transport. The protein localises to the cytosol, nucleus, plasmalemma, yeast-form cell wall, hyphal cell wall, and fungal biofilm matrix. Associations with respiration rate, biomass yield, oxidative stress, and altered vegetative growth, chronological lifespan, competitive fitness, vacuolar morphology, and chemical resistance have been noted. Studies of related pyruvate decarboxylases in other species link the family to EC 4.1.1.1.