KIN28 — Saccharomyces cerevisiae S288c

Summary

YDL108W, also known as CRK1 or KIN28 on chromosome IV of Saccharomyces cerevisiae S288c, encodes a cyclin-dependent protein kinase with RNA polymerase II C-terminal domain S2 and S5 kinase activity, ATP binding, and cyclin binding. It is a component of the TFIIK and holo TFIIH complexes and localizes to the meiotic spindle and spindle pole body. The gene is associated with mRNA stabilization and processing, cytokine production, regulation of cellular response to glucose starvation, and positive regulation of mediator complex assembly and protein breakdown. Phenotypic associations include arrested exponential-phase growth, decreased autophagy, increased heat sensitivity, inviability, and altered chemical resistance. Studies of related genes in other species link the family to protein serine/threonine kinase activity and EC 2.7.11.23.