COP1 — Saccharomyces cerevisiae S288c

Summary

YDL145C in Saccharomyces cerevisiae S288c encodes a protein with cargo receptor activity, dynein complex binding, microtubule plus-end binding, structural molecule activity, and GTP binding. It contains WD40 repeat domains and is a component of the coatomer complex, associated with Golgi membranes, microtubules, spindle poles, kinetochores, and the nuclear envelope. The gene is linked to diverse biological processes including vesicle transport along microtubules, endosomal transport, mitotic spindle orientation, photomorphogenesis, photosynthesis, cotyledon and seedling development, anthocyanin anabolism, ABA signaling, cellular respiration, and DNA integrity checkpoint. It is also associated with traits such as stomatal opening and salt tolerance, and with phenotypes including abnormal protein secretion, decreased vegetative growth, altered chemical resistance, and inviability. Related genes in other species connect the family to photomorphogenesis and seedling development.