GAL3 — Saccharomyces cerevisiae S288c

Summary

YDR009W (GAL1/GAL3) on chromosome IV of Saccharomyces cerevisiae S288c encodes a protein with galactokinase activity and ATP binding, placing it in the GHMP kinase family. The gene is associated with a wide range of biological processes including hatching, mRNA modification, RNA retention, response to X-ray, short-term and long-term memory, alkaloid and sphingolipid anabolism, regulation of unsaturated fatty acid anabolism, glycogenolysis, lactose metabolism, depurination, antibody production, and phosphatidylserine anabolism. It is linked to traits such as amylose content, germinability at low temperature, male sterility, copper and iron concentration, potassium uptake, salt sensitivity, biomass yield, protein content, acid sensitivity, and oxidative stress. Phenotypic associations include decreased anaerobic growth, altered carbon source utilization, abnormal chemical compound accumulation, decreased competitive fitness, and altered chemical resistance. The protein localises to the cytoplasm and cytosol. Studies of related genes in other species link the family to galactokinase (EC 2.7.1.6) activity.