MSH6 — Saccharomyces cerevisiae S288c

Summary

YDR097C (MSH6) on Saccharomyces cerevisiae chromosome IV encodes a member of the MutS family of DNA mismatch repair proteins. The product possesses ATP hydrolase activity, binds G/T mispairs, heteroduplex DNA loops, double-strand/single-strand DNA junctions, Y-form DNA, and dsDNA, and acts as an ATP-dependent DNA damage sensor. MSH6 is associated with mismatch repair, meiotic mismatch repair, removal of nonhomologous ends, maintenance of DNA repeat elements, heteroduplex formation, homologous recombination, gene conversion at the mating-type locus, mitochondrial DNA repair, error-free post-replication repair, interstrand crosslink repair, and response to cisplatin. It localises to the MutSbeta complex, nuclear chromosome, sites of double-strand breaks, cytosol, and nucleus. Phenotypic associations include increased mutation frequency and mitotic recombination, decreased chronological lifespan and oxidative stress resistance, altered chemical compound accumulation, and abnormal vacuolar and actin cytoskeleton morphology.