SWI5 — Saccharomyces cerevisiae S288c

Summary

YDR146C in Saccharomyces cerevisiae S288c encodes a C2H2-type zinc-finger DNA-binding transcription activator specific for RNA polymerase II. The protein binds 14-3-3 proteins and sequence-specific DNA in cis-regulatory regions. It localises to the nucleus, cytoplasm, cytosol, and chromatin, and is a component of the Tec1p-Ste12p-Dig1p and Ste12p-Dig1p-Dig2p complexes. YDR146C is associated with biofilm formation, cell adhesion in single-species biofilms, cytokinesis, septin ring disassembly, cell fate determination, and positive regulation of antisense RNA transcription. It is linked to responses including cold, acidic pH, oxidative stress, and mechanical stimulus, as well as negative regulation of signalling, regulation of the apoptotic process, and unsaturated fatty acid anabolism. Phenotypic associations include decreased UV and metal resistance, increased replicative lifespan, altered cell cycle progression in G1 phase, and abnormal colony and liquid culture appearance. Studies of related genes in other species link the family to pathogenicity and virulence.