SEC7 — Saccharomyces cerevisiae S288c

Summary

YDR170C, also known as SEC7, encodes a protein on chromosome IV of Saccharomyces cerevisiae S288c that contains a Sec7 domain, a DCB domain, and an ARM-type fold, and is associated with GDS activity, lipid binding, and metal binding. The gene is associated with secretion by the cell, vesicle tethering, membrane assembly, and glycoprotein transport, as well as COPI vesicle budding, macroautophagy, and regulation of ARF protein signal transduction. It localises to the Golgi membrane, COPI and COPII coated vesicle membranes, the cell tip, and the cell division site. Phenotypic associations include abnormal endomembrane system and vacuolar morphology, decreased protein secretion, increased chitin deposition, increased heat sensitivity, altered toxin resistance, and inviability. Studies of related genes in other species link the family to similar secretory and membrane-trafficking processes.