SIR4 — Saccharomyces cerevisiae S288c

Summary

YDR227W, also known as SIR4 in Saccharomyces cerevisiae S288c, encodes a protein containing a SIR4_SID domain. The gene is associated with telomere maintenance, telomeric silencing, and chromosome organization. It is linked to sexual reproduction, transposition, meiosis, and filamentous growth. YDR227W is associated with DNA protection, DNA integration, canonical nonhomologous end joining, and chromatin modeling. Phenotypic associations include decreased telomere length, altered silencing, sterility, absent mating response and shmoo formation, and abnormal sporulation. The gene is also associated with decreased replicative lifespan, increased bipolar budding, abnormal protein transport, and altered stress resistance, including decreased oxidative stress resistance and increased killer toxin resistance.