SWR1 — Saccharomyces cerevisiae S288c

Summary

YDR334W (SWR1) in Saccharomyces cerevisiae S288c encodes a protein with ATP-dependent H2AZ histone chaperone activity, structural molecule activity, helicase activity, histone binding, ATP hydrolase activity, DNA binding, and ATP binding. It is a component of the SWR-C complex and localises to the nucleus and cytosol. The gene is associated with interphase, phosphate metabolism, response to abiotic and thermal stimuli, lipid homeostasis, systemic acquired resistance, DNA damage checkpoint, regulation of DNA binding, organogenesis, pollen germination, double-strand break repair, RNA-protein complex biogenesis, maintenance of sister chromatid cohesion, cell wall organisation, regulation of chromatin organisation, rDNA packaging, homologous recombination, and detoxification. Phenotypic associations include increased innate thermotolerance and chronological lifespan, decreased UV resistance, oxidative stress resistance, and heat sensitivity, as well as abnormal nuclear transport and vacuolar morphology. Related genes in other species are linked to the enzyme class 3.6.4.12.