DOT1 — Saccharomyces cerevisiae S288c

Summary

YDR440W in Saccharomyces cerevisiae S288c encodes Dot1, a protein with histone H3K79 methylase and trimethylase activities, as well as histone-binding capability. The protein localises to the nucleosome, nucleus and telomeric regions. YDR440W is associated with numerous biological processes including chromatin silencing, telomeric silencing, the DNA damage checkpoint, homologous recombination, bypass DNA synthesis, the pachytene checkpoint, response to heat and ionizing radiation, regulation of ribosome biogenesis and DNA repair, S phase, chromatin decompaction, methylation, antigenic variation, V-J joining, and the Wg signaling pathway. The gene is linked to traits such as oxidative stress and to phenotypes including abnormal telomere length, increased X-ray resistance, decreased gamma ray resistance, increased heat sensitivity, decreased chronological lifespan, decreased vegetative growth, abnormal silencing, increased mutation frequency, and altered chitin deposition, protein accumulation and vacuolar morphology. Studies of related genes in other species link the family to the enzyme class 2.1.1.360.