SRB4 — Saccharomyces cerevisiae S288c

Summary

YER022W (SRB4) on chromosome V of Saccharomyces cerevisiae S288c encodes a component of the Mediator complex and is associated with the Med17 domain. It is annotated as a transcriptional co-regulator with RNA polymerase II complex recruiting activity, DNA-binding transcription factor binding, and core promoter sequence-specific DNA binding. The gene is associated with transcription by RNA polymerase II, including positive regulation of transcription initiation and elongation, as well as regulation of gene expression. It has been linked to diverse processes such as Golgi vesicle transport, vacuolar transport, pexophagy, protein glycosylation, fatty acid breakdown, arginine anabolism, lipid metabolism, mitochondrial genome maintenance, double-strand break repair, cellular response to heat, and structural organization. Phenotypic associations include decreased RNA accumulation, decreased innate thermotolerance and starvation resistance, altered toxin resistance, increased heat sensitivity, inviability, decreased vegetative growth and competitive fitness, and haploinsufficiency. Studies of related genes in other species further connect the family to these core transcriptional regulatory functions.