SSA4 — Saccharomyces cerevisiae S288c

Summary

YER103W (SSA4) on chromosome V of Saccharomyces cerevisiae S288c encodes a member of the Hsp70 family of ATP-dependent protein folding chaperones, with ATP hydrolase activity, peptide and unfolded protein binding, and heat shock protein binding functions. It also acts as a transcriptional co-regulator. The gene is associated with the regulation of protein folding, response to stress, translation termination, ribosome assembly, ethanol fermentation, and release of cytochrome c from mitochondria. It is linked to traits including male sterility, iron concentration, phosphate content, protein content, and oxidative stress, as well as phenotypes such as decreased replicative and chronological lifespan, decreased cell size, absent respiratory growth, decreased starvation resistance, and decreased vegetative growth rate. The protein localises to the fungal-type cell wall, biofilm matrix, and extracellular space.