PAB1 — Saccharomyces cerevisiae S288c

Summary

YER165W in Saccharomyces cerevisiae S288c encodes a poly(A)-binding protein (PABP) with RNA nuclease inhibitor activity, phase separation nucleator activity, and RNA, poly(A), poly(U), and mRNA 3′-UTR binding activities. The protein localises to the cytoplasm, nucleus, ribosome, stress granules, and ribonucleoprotein complexes. It is associated with mRNA metabolism, translation initiation and its regulation, mRNA stabilisation, poly(A) tail shortening, nuclear export, protein kinase A and PKC signalling, invasive growth, constitutive heterochromatin assembly, response to hypoxia and UV-A, stress granule assembly, and GMP anabolism. Phenotypic associations include increased invasive growth and toxin resistance, decreased vegetative growth rate and competitive fitness, heat sensitivity, G1 cell-cycle arrest, abnormal mitochondrial morphology, reduced protein accumulation, and inviability. Related genes in other species link the family to poly(A)-binding domains.