CAK1 — Saccharomyces cerevisiae S288c

Summary

YFL029C in Saccharomyces cerevisiae S288c encodes a cyclin-dependent protein kinase (CDK) with serine/threonine kinase activity, ATP binding, and cyclin binding capabilities. It is a component of the Pho85-Pho80 CDK-cyclin complex and localizes to the meiotic spindle, spindle pole body, and telomeric regions. The gene is associated with cell cycle control, including meiotic S phase, meiosis I, spore wall assembly, and regulation of mitotic cell cycle phase transitions and DNA replication. It is linked to responses to trehalose, lipid, and glucose starvation, as well as negative regulation of anaphase-promoting complex activity and primary cell septum biogenesis. Phenotypic associations include abnormal spore wall formation, cytokinesis, and septum formation, increased heat sensitivity, decreased thermotolerance, altered alkaline pH resistance, and changes in protein activity and accumulation.