PES4 — Saccharomyces cerevisiae S288c

Summary

YFR023W in Saccharomyces cerevisiae S288c encodes a protein with RNA nuclease inhibitor activity, phase separation nucleator activity, and poly(A), poly(U), and mRNA 3′-UTR binding capabilities. It is associated with Protein Kinase A signaling, invasive growth, nuclear export, response to hypoxia, regulation of translational initiation and mRNA stability, translational readthrough, PKC signal transduction, chromosome division, S phase, meiosis, mitosis, nucleosome disassembly, and stress granule assembly. The protein localizes to the ribosome, stress granules, cytoplasm, cytosol, and nucleus. Phenotypic associations include increased invasive growth, decreased vegetative growth and competitive fitness, altered chemical resistance, and normal sporulation. Studies of related genes in other species link the family to thioredoxin-like domains and fatty acid hydroxylase activity, though these functions are not established for YFR023W itself.