CDC14 — Saccharomyces cerevisiae S288c

Summary

YFR028C, also known as CDC14, encodes a protein with protein tyrosine/serine/threonine phosphatase activity on chromosome VI of Saccharomyces cerevisiae S288c. The gene is associated with mitotic cell cycle regulation, including mitotic anaphase, spindle organization, spindle elongation, and mitotic exit, as well as meiosis I, meiotic spindle breakdown, and cytokinesis. It is linked to rDNA packaging, negative regulation of transcription by RNA polymerase I, protein localization to the mitotic spindle pole body, and cell septum assembly. The phosphatase localizes to the RENT complex, spindle pole body, mitotic spindle midzone, and actomyosin contractile ring. Phenotypic associations include cell cycle arrest in late anaphase, absent cytokinesis, increased autophagy, abnormal actin cytoskeleton morphology, increased mitotic recombination, absent sporulation, and altered heat and chemical sensitivities. Studies of related genes in other species link the family to protein tyrosine phosphatase activity (EC 3.1.3.48).