RAD6 — Saccharomyces cerevisiae S288c

Summary

YGL058W (RAD6) in Saccharomyces cerevisiae S288c encodes a ubiquitin-conjugating enzyme (E2) with ubiquitin-protein transferase activity, ssDNA-dependent ATPase activity, ssDNA binding, ATP binding, and proteasome binding. The gene is associated with recombinational repair, postreplication repair, homologous recombination, DNA recombination, gene conversion, mitotic recombination, telomere capping, telomeric silencing, deubiquitination, thioester and adenine anabolism, response to MMS, cell killing, transposition, prophase, ovulation, protein localization, and the Tl signaling pathway. It localizes to the Rad6-Rad18, RAD6-UBR2, UBR1-RAD6, MUB1-RAD6-UBR2, and HULC complexes, as well as the nucleus, cytoplasm, chromosome telomeric region, and fungal biofilm matrix. The gene is linked to traits including calcium, oxidative stress, light, and acid sensitivity, and phenotypes such as decreased UV and gamma ray resistance, increased mutation frequency, abnormal transposition, decreased telomere length, and altered sporulation, biofilm formation, and filamentous growth.