RAD54 — Saccharomyces cerevisiae S288c

Summary

YGL163C in Saccharomyces cerevisiae S288c encodes a protein with histone octamer slider activity, nucleosome array spacer activity, DNA translocase activity, TBP-class protein binding, centromere binding, histone carrier activity, ATP-dependent chromatin remodeler activity, nucleosome binding, chromatin adaptor activity, helicase activity, GTF2 activity, histone binding, ssDNA binding, and chromatin binding. The gene is associated with cell cycle phase, strand invasion, cell killing, bypass DNA synthesis, mating type switching, recombinational repair, G2 phase, DNA recombination, BER, spindle assembly checkpoint, DNA metabolism, postreplication repair, HDR, gene conversion, response to heat, protein-DNA complex remodeling, cell cycle checkpoint, and response to X-ray. It localizes to SHREC complex, nuclear microtubule, CHRAC, CENP-A containing chromatin, SWI-SNF complex, PBAF complex, heterochromatin island, rDNA heterochromatin, subtelomeric heterochromatin, and condensed chromosome centric region. Phenotypic associations link YGL163C to absent mating type switching, increased mutation frequency, decreased G1 phase duration, decreased X-ray resistance, decreased apoptosis, decreased gamma-ray resistance, decreased spore germination, increased sporulation efficiency, decreased mitotic recombination, increased transposable element transposition, abnormal endoplasmic reticulum morphology, abnormal nuclear morphology, abnormal cellular morphology, abnormal bud morphology, decreased resistance to enzymatic treatment