SPT16 — Saccharomyces cerevisiae S288c

Summary

YGL207W, also known as SPT16 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a subunit of the FACT complex with H2A-H2B histone carrier activity, histone binding, and nucleosome binding functions. The gene is associated with nucleosome assembly and disassembly, DNA replication, DNA repair, regulation of transcription elongation, cell cycle control, and constitutive heterochromatin assembly. It has been connected to euchromatin and nuclear localization, as well as to processes including mating, asymmetric cell division, and co-transcriptional chromatin reassembly. Associations with traits include oxidative stress, and phenotypes linked to the gene encompass cell cycle arrest in G1 phase, abnormal cellular morphology, decreased nucleolus size, increased mutation frequency, heat sensitivity, inviability, and altered vegetative growth and chemical resistance.