ERG1 — Saccharomyces cerevisiae S288c

Summary

YGR175C (ERG1) on chromosome VII of Saccharomyces cerevisiae S288c encodes squalene monooxygenase, a FAD-binding enzyme. The gene is associated with ergosterol, sterol, triterpenoid, and zymosterol anabolism, as well as the isoprenoid pathway, and has been connected to response to miconazole, NADPH regeneration, and cell growth mode switching from budding to filamentous. It is linked to lipid, starch, alanine, proline, mannose, thiamin, and protein metabolism, and to nitric oxide storage. The protein localizes to the endoplasmic reticulum membrane, vacuolar membrane, plasma membrane, cytoplasm, and adiposomes. Phenotypic associations include abnormal lipid particle and mitochondrial morphology, increased innate thermotolerance and invasive growth, altered chemical compound accumulation, and increased heat sensitivity. Studies of related genes in other species link the family to FAD-dependent oxidoreductase activity (EC 1.14.14.17).