RIE1 — Saccharomyces cerevisiae S288c

Summary

YGR250C, also known as PAB1 or RIE1 on chromosome VII of Saccharomyces cerevisiae S288c, encodes a protein with RNA nuclease inhibitor activity, phase separation nucleator activity, and promoter-specific chromatin binding. It binds poly(A), poly(U), mRNA 3′-UTRs, and RNA generally. The gene is associated with regulation of translational initiation, mRNA stability, poly(A) tail shortening, nonsense-mediated mRNA decay, and mRNA 3′-end processing. It is linked to stress granule assembly, response to hypoxia, UV, and UV-A, as well as PKC signal transduction, cell death, karyogamy, and protein refolding. The product localizes to ribosomes, stress granules, ribonucleoprotein complexes, the cytoplasm, cytosol, and nucleus. Associations with traits include oxidative stress, and phenotypes such as altered critical cell size at the G1 checkpoint, abnormal colony appearance, auxotrophy, altered protein accumulation, decreased stress resistance, and changes in competitive fitness.