ERG11 — Saccharomyces cerevisiae S288c

Summary

YHR007C (ERG11) in Saccharomyces cerevisiae S288c encodes a cytochrome P450 sterol 14-demethylase, a heme-binding monooxygenase with oxidoreductase activity that acts on paired donors with incorporation of molecular oxygen. The gene product is localized to the endoplasmic reticulum membrane, including perinuclear and cortical ER, and also associates with the plasma membrane. YHR007C is associated with sterol anabolism, ergosterol metabolism, steroidogenesis, and sterol homeostasis, as well as with membrane polarization, endosome organization, and Golgi vesicle transport. It has been linked to cell growth, the switch from budding to filamentous growth, and mRNA transcription. Associations include decreased invasive growth, increased heat sensitivity, altered metal and toxin resistance, reduced vegetative growth and competitive fitness, and inviability under certain conditions. Studies of related genes in other species link the family to lethality and loss of pathogenicity.