SOD2 — Saccharomyces cerevisiae S288c

Summary

YHR008C (SOD2) in Saccharomyces cerevisiae S288c encodes a manganese superoxide dismutase with superoxide dismutase activity and manganese binding, localizing to the mitochondrial lumen, mitochondria, and cytosol. This gene is associated with response to oxidative stress, electron transport chain, oxidative phosphorylation, mitochondrial biogenesis, and oxygen metabolism. It is linked to lysine metabolism and anabolism, aflatoxin and mycose biosynthesis, protein ubiquitination, cadmium transport, regulation of potassium transport, and evasion of host-produced AOS. Associations include traits such as manganese content, photosynthetic rate, sodium concentration, copper sensitivity, iron concentration, phosphate content, and oxidative stress. Phenotypic associations include decreased viability, survival rate, replicative and chronological lifespan, stress resistance, and sporulation, alongside increased apoptosis, necrotic cell death, and prion formation. Studies of related genes in other species link the family to EC 1.15.1.1 and unaffected pathogenicity.