NEL1 — Saccharomyces cerevisiae S288c

Summary

YHR035W, also known as NEL1 or SEC23, encodes a protein with GTPase-activating protein (GAP) activity and zinc-binding capability. The protein localises to the ER exit site, COPII vesicle coat, Golgi and ER membranes, cytosol and nucleus. It is associated with COPII vesicle cargo loading and selection, vesicle transport, targeting, tethering and fusion, membrane tubulation, pore formation, ER-phagy, nuclear pore complex assembly, intra-Golgi and cis-Golgi to rough ER transport, fermentation, cellular homeostasis, mitotic checkpoint, protein positioning, embryonic cleavage and syngamy. Phenotypic associations include haploproficiency, viability, altered chronological lifespan, altered competitive fitness, and both increased and decreased resistance to chemicals. Studies of related genes in other species link the family to COPII vesicle function.