IRE1 — Saccharomyces cerevisiae S288c

Summary

YHR079C (IRE1) encodes a protein with serine/threonine protein kinase activity, RNA endonuclease activity, cyclin-dependent protein kinase activity, calmodulin binding, and unfolded protein binding. In Saccharomyces cerevisiae, IRE1 is associated with the endoplasmic reticulum stress response, the ER-nuclear signaling pathway, protein denaturation, phospholipid metabolism, meiosis, sporulation, and the cell cycle. It localizes to the ER, nucleus, cytoplasm, and the TFIIH complex. The gene is linked to numerous phenotypes including decreased viability, altered sporulation, abnormal ER and vacuolar morphology, increased autophagy, altered RNA and protein accumulation, decreased meiotic and mitotic recombination, increased prion formation, and altered stress resistance. Studies of related genes in other species connect the IRE1 family to the IRE1 branch of the unfolded protein response and to loss of pathogenicity.